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Top-10 Cat Flea And Tick Preventions
Loved in the USA

Handpicked for quality & trusted by thousands of customers

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NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#1
Top Rated in the USA
PetArmor P
PetArmor

Born in the USA

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

19%OFF

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10.0
58 634 reviews

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1 318 bought in past month

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NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#2
FRONTLINE
Frontline

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 6 Treatments

22%OFF

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9.7
49 041 reviews

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1 216 bought in past month
Last Purchases
Am***ia
Chicago, IL
2d ago
L***y
Miami, FL
2d ago
Ha***er
Miami, FL
1d ago
#3
Advantage
Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention Cats Over 9 lbs. 2-Month Supply

5%OFF

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8.8
76 936 reviews

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1 114 bought in past month
Exceptional quality without breaking the bank.
JenniferLos Angeles, CA
#4
Seresto Ca
Seresto

Born in the USA

Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats, 8 Months Protection (Pack of 2)

18%OFF

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8.2
43 753 reviews

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1 012 bought in past month
Curated products trusted bytrust us brands
#5
Capstar (n
Capstar

Born in the USA

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 12 Doses (Includes Two 6-Count Boxes)

15%OFF

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7.3
40 066 reviews

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910 bought in past month
#6
Revolution
Revolution Plus

Born in the USA

Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 11.1-22 lbs (Green), 6 Tubes

5%OFF

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7.3
115 reviews

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808 bought in past month
#7
Capstar (n
Capstar

Born in the USA

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

Fast Delivery
7.3
40 066 reviews

Solid Value from a Trusted Brand

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706 bought in past month
#8
Advecta Pl
Advecta

Born in the USA

Advecta Plus Topical Large Cat Flea Treatment for Cats and Kittens, Flea Prevention and Control, Fast-Acting Waterproof Drops, 6-Month Supply

5%OFF

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7.0
12 157 reviews

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604 bought in past month
#9
Advantage
Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention Cats 5-9 lbs. 2-Month Supply

5%OFF

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7.0
38 130 reviews

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502 bought in past month
#10
Seresto La
Seresto

Born in the USA

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. 2-Pack

18%OFF

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7.0
111 441 reviews

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400 bought in past month

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Revolution
Revolution Plus

Born in the USA

Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 5.6-11 lbs (Orange), 3 Tubes

5%OFF

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115
verified reviews

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298 bought in past month
NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent and Control, Fast Acting Waterproof Topical Drops, Flea Prevention for Cats Over 3.5 lbs, 3 Monthly Doses

10%OFF

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1 713
verified reviews

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196 bought in past month
PetArmor C
PetArmor

Born in the USA

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Cat Flea Treatment Pill, Fast Acting Tablets Start Killing in 30 Minutes, 2-25 lbs, 6 Doses

5%OFF

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17 365
verified reviews

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94 bought in past month
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Catego for
Catego

Catego for Cats Flea and Tick Treatment & Prevention (Over 1.5 lbs) 6-Month Supply

Fast Delivery
5 941
verified reviews

Solid Value from a Trusted Brand

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ADAMS Plus
Adams

Born in the USA

ADAMS Plus Flea & Tick Shampoo with Precor IGR for Cats, Kittens, Dogs & Puppies Over 12 Weeks of Age, Sensitive Skin Flea Treatment, Kills Adult Fleas, Flea Eggs, Ticks, and Lice, 24 Ounces

35%OFF

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31 619
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Our Top Picks

#1

Winner

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Rating
10.0
Chosen by1,318
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
58634 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.

PetArmor Plus Flea and Tick Prevention for Cats is a topical treatment designed for cats weighing over 1.5 pounds and aged 8 weeks or older. It contains the active ingredients fipronil and (s)-methoprene, which work together to kill fleas, flea eggs, larvae, ticks, and chewing lice. One of its strong points is that it helps break the flea life cycle, which means it doesn't just kill adult fleas but also prevents new infestations by targeting eggs and larvae. The formula is waterproof and fast-acting, starting to work within 24 hours and providing protection for up to 30 days per application. The pack includes 12 doses, enough to cover a full year of monthly treatment. It’s easy to apply by parting the cat’s fur at the shoulder blades and squeezing on the drops. Because the product can leave a greasy residue for about two days, you might need to clean the area gently if it seems excessive.

PetArmor Plus is unscented and allergen-free, which is helpful for sensitive cats. While generally safe if used as directed, it’s important to keep treated cats away from other pets and children until the product dries. Some users have reported mild side effects like temporary irritation, but this is uncommon. This product suits cat owners looking for a reliable, veterinarian-quality flea and tick treatment that is straightforward to use and provides lasting protection. It may not be ideal if you prefer natural or oral treatments, or if your cat is under 1.5 pounds.

Rating
10.0
Chosen by1,318
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
58634 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.
#2

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 6 Treatments

Rating
9.7
Type of Prevention
Duration of Effectiveness
Side Effects and Safety

Most important from
49041 reviews

Type of Prevention
This treatment effectively controls fleas and ticks when applied correctly every 30 days, providing reliable protection that helps keep cats comfortable and healthy.
Duration of Effectiveness
Consistent monthly application is crucial; missing doses or washing the treated area too soon can diminish the product's effectiveness.
Side Effects and Safety
This product offers good value compared to others on the market and rarely causes adverse effects when used as directed.
Ease of Application
Applying the product at the base of the skull, rather than between the shoulder blades, ensures the cat cannot reach it and makes application easier and more efficient.

Frontline Plus Flea and Tick Treatment for Cats is a popular option designed for cats weighing 1.5 pounds or more, including kittens from 8 weeks old. It combines two active ingredients, fipronil and (S)-methoprene, which work together to kill adult fleas, flea eggs, larvae, chewing lice, and ticks that can carry diseases like Lyme. This combination helps break the flea life cycle, reducing the chance of future infestations.

One of its key strengths is that it provides waterproof protection lasting a full 30 days, making it convenient to apply only once a month. The treatment is applied as a small liquid spot on the back of the neck where the cat can’t lick it off, which is fairly simple but requires careful application to avoid contact with the treated area until dry. Frontline Plus has been trusted by pet owners for over 20 years and is widely available.

It’s important to note that it’s not suitable for cats under 8 weeks or under 1.5 pounds, so very young or small cats need a different solution. Some cats may experience mild side effects like skin irritation, but serious reactions are rare if used correctly. Since fleas can come indoors even with indoor cats, this treatment also helps protect the entire household when used consistently. Frontline Plus is a reliable and effective monthly flea and tick prevention for most cats, especially house cats, but it requires careful adherence to weight, age limits, and application instructions to keep your pet safe.

Rating
9.7
Type of Prevention
Duration of Effectiveness
Side Effects and Safety

Most important from
49041 reviews

Type of Prevention
This treatment effectively controls fleas and ticks when applied correctly every 30 days, providing reliable protection that helps keep cats comfortable and healthy.
Duration of Effectiveness
Consistent monthly application is crucial; missing doses or washing the treated area too soon can diminish the product's effectiveness.
Side Effects and Safety
This product offers good value compared to others on the market and rarely causes adverse effects when used as directed.
Ease of Application
Applying the product at the base of the skull, rather than between the shoulder blades, ensures the cat cannot reach it and makes application easier and more efficient.
#3

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

Rating
8.8
Side Effects and Safety
Ease of Application

Most important from
76936 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention is specifically designed for large cats over 9 lbs and at least 8 weeks old. This product stands out as an easy-to-apply monthly topical treatment that eliminates the need for hard-to-swallow pills and does not require a prescription. It's effective against adult fleas, flea larvae, and flea eggs, providing comprehensive protection.

The treatment starts working within 12 hours of application and remains effective for 30 days, ensuring continuous flea control for a month. Additionally, it is fragrance-free and waterproof, making it suitable for cats' daily activities after 24 hours of application. The active ingredients, Imidacloprid and Pyriproxyfen, are known for their efficacy in flea control.

It is crucial to follow the application instructions carefully to avoid any adverse effects, such as getting the product in the cat's eyes or ingestion. While the product is generally safe, some cats might experience mild side effects like skin irritation. The ease of application is greatly appreciated by pet owners, as it simplifies the process of flea prevention. This product is highly recommended for large cats who need reliable and effective flea treatment without the hassle of pills.

Rating
8.8
Side Effects and Safety
Ease of Application

Most important from
76936 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Buying Guide for the Best Cat Flea And Tick Preventions

Choosing the right flea and tick prevention for your cat is crucial for their health and comfort. Fleas and ticks can cause a range of issues from mild irritation to serious diseases. When selecting a product, consider your cat's lifestyle, health status, and any specific needs they may have. It's important to understand the different types of preventions available and how they work to make an informed decision that best suits your cat's needs.
Type of PreventionFlea and tick preventions come in various forms such as topical treatments, oral medications, collars, and shampoos. Topical treatments are applied directly to the cat's skin and are effective for a month. Oral medications are ingested and can provide protection for up to three months. Collars release active ingredients over time and can last for several months. Shampoos provide immediate relief but need to be used regularly. Choose the type based on your cat's tolerance and your convenience.
Active IngredientsThe active ingredients in flea and tick preventions are what kill or repel the pests. Common ingredients include fipronil, imidacloprid, and fluralaner. Each ingredient works differently and may target different stages of the flea or tick lifecycle. It's important to choose a product with ingredients that are safe for cats and effective against the specific pests in your area. Consult your vet to determine which active ingredients are best for your cat.
Duration of EffectivenessThe duration of effectiveness refers to how long the prevention will protect your cat from fleas and ticks. This can range from a few days with shampoos to several months with collars. Consider how often you are willing to reapply or administer the prevention. For busy pet owners, longer-lasting options like collars or oral medications might be more convenient.
Age and Weight RestrictionsMany flea and tick preventions have age and weight restrictions to ensure safety and effectiveness. Products are often formulated for specific age groups, such as kittens or adult cats, and weight ranges. Always check the product label to ensure it is appropriate for your cat's age and weight. Using a product not suited for your cat can lead to ineffective treatment or potential health risks.
Side Effects and SafetyAll flea and tick preventions have the potential for side effects, which can range from mild skin irritation to more serious reactions. It's important to read the product label and consult with your vet about any potential side effects, especially if your cat has a history of allergies or sensitivities. Choose a product with a good safety profile and monitor your cat for any adverse reactions after application.
Ease of ApplicationThe ease of application can vary significantly between different types of flea and tick preventions. Topical treatments and collars are generally easy to apply, while oral medications may require more effort if your cat is resistant to taking pills. Shampoos require regular bathing, which can be challenging if your cat dislikes water. Consider your cat's temperament and your ability to administer the treatment when choosing a product.

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